Butylone crystal

Butylone
Chemical Nomenclature
Common names	Butylone, bk-MBDB, B1
Substitutive name	β-keto-N-methylbenzodioxolylbutanamine
Systematic name	1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one
Class Membership
Psychoactive class	Stimulant / Entactogen
Chemical class	Cathinone
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. CollapseOral Dosage Threshold Common Heavy 20 – 40 – 80 – 125 – 225 mg Light Strong Threshold 20 – 40 mg Light 40 – 80 mg Common 80 – 125 mg Strong 125 – 225 mg Heavy 225 mg + Duration Total 3 – 5 hours Onset 15 – 60 minutes Peak 60 – 120 minutes Offset 60 – 120 minutes After effects 4 – 12 hours

Chemistry

Butylone, or β-keto-N-methylbenzodioxolylbutanamine, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines in that they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional ethyl substitution at R_α. Cathinones such as butylone are alpha-methylated phenethylamines (i.e. amphetamines) but differ from them with the addition of a ketone functional group (a carbonyl group at R_β). Butylone contains a methyl substitution at R_N, a substitution which is shared with MDEA, ethylone, 4-MEC, and certain other stimulants and entactogens. Additionally, butylone contains substitutions at R₃ and R₄ of the phenyl ring with oxygen groups. These oxygen groups are incorporated into a methylenedioxy ring through a methylene chain. Butylone shares this methylenedioxy ring with MDA, MDAI and MDMA.

Pharmacology

Butylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.^[2][3] These are the neurotransmitters in charge of pleasure, reward, motivation and focus. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate and be reused, causing physically stimulating and euphoric effects.

In comparison to methylone, Butylone crystal has approximately over 4x lower affinity for the norepinephrine transporter, while its affinity for the serotonin and dopamine transporters is similar.^[4][5] The results of these differences in pharmacology relative to MDMA is that butylone, like its close analog ethylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, butylone still has relatively robust releasing capabilities.